A Study to Compare Two Anti-HIV Drug Combinations That Include Amprenavir in HIV-Infected Patients Who Have Failed Anti-HIV Drug Combinations That Did Not Include Amprenavir

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare the safety and effectiveness of two anti-HIV drug combinations in fighting HIV infection in patients whose viral loads (levels of HIV in the blood) rose with other anti-HIV drug treatments.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Glaxo Wellcome
• Treatments: Abacavir; Amprenavir; Indinavir; Lamivudine; Nelfinavir

Criteria

Inclusion Criteria

You may be eligible for this trial if you:

• Are HIV-positive.

• Are 13 years of age or older.

• Are currently taking anti-HIV drugs, 1 of which must be NFV or IDV, and have taken these same drugs for at least 12 weeks.

• In the last 16 weeks your viral load (level of HIV in the blood) dropped below 400 copies/ml and has since increased to at least 1,000 copies/ml, even though you continue to take your anti-HIV drugs.

• Have the written consent of a parent or legal guardian if you are under age 18.

• Agree to practice abstinence or use effective barrier methods of birth control (unless you are physically incapable of becoming pregnant).

• Are willing to complete the 48-week study.

Exclusion Criteria

You will not be eligible for this trial if you:

• Have ever taken the following anti-HIV drugs: ABC, APV, efavirenz (EFV), delavirdine (DLV), nevirapine (NVP), or loviride.

• Have certain AIDS-related infections or diseases, have other serious medical conditions such as diabetes and certain types of heart trouble, or have a history of lymphoma.

• Have had certain types of hepatitis in the past 6 months.

• Have received an HIV vaccine in the past 3 months or a flu vaccine in the past 30 days.

• Have certain digestion problems that make it difficult to take anti-HIV drugs by mouth.

• Have received certain other drugs or treatments in the past 30 days, or will need certain drugs or treatments during the study.