A Study to Compare the Effects of Different Sized Particles on Cells in the Nose

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to see how the type and size of particles found in air pollution affects inflammation in the nose in people who are skin test positive to at least one allergen. It has been observed that pollution makes allergies worse. It has also been suggested that very small particles may affect allergies more than larger particles.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID); University of California, Los Angeles
• Collaborator: National Institute of Allergy and Infectious Diseases (NIAID)

Criteria

Inclusion Criteria:

• Previously determined high inflammatory responders to Diesel Exhaust Particles

• Previously determined atopy as demonstrated by allergy skin testing

• Asymptomatic on day of challenge.

Exclusion Criteria:

• History of lung problems (including asthma), bleeding, neuromuscular, liver, kidney or heart disorders.

• History of anaphylaxis.

• Recent upper respiratory infection (less than 4 weeks prior to study) or other active infection.

• Active smoker or smoker in the past 2 years.

• Treatment with topical nasal steroids (< 1 month), systemic steroids (<1 month), oral antihistamines (< 1 week) prior to any nasal challenge.

• Use of leukotriene receptor antagonist (< 1 month ) prior to any nasal challenge

• Intranasal antihistamine or cromolyn use < 1 week prior to any nasal challenge .

• History of treatment with allergy immunotherapy.

• Inability to perform nasal lavage.

• Inability to give written informed consent

• Pregnancy