A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
Status:
Completed
Trial end date:
2017-05-01
Target enrollment:
Participant gender:
Summary
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies
clear the anesthetic. Most people wake quickly, but some do not. All patients have memory and
other cognitive problems after waking from anesthesia. In studies on animals, the
investigators observed that caffeine caused rats and mice to wake much more rapidly from
anesthesia. This was true for all the animals tested. The investigators would like to see if
this holds true in humans. Will caffeine accelerate waking from anesthesia? Will it reverse
the cognitive deficits associated with anesthesia, after waking?
The investigators carried out a modest trial with 8 test subjects. Each volunteer was
anesthetized twice. Each volunteer was anesthetized one time and received an infusion of
saline (placebo control), without the aid of any other drugs and the other time the volunteer
received an infusion of a relatively low dose of caffeine. The order of saline versus
caffeine was randomized and the study was done in a double blind manner. We observed that
emergence from anesthesia was significantly accelerated by the caffeine infusion. No adverse
events were observed.
Phase:
Phase 4
Details
Lead Sponsor:
University of Chicago
Collaborators:
National Institute of General Medical Sciences (NIGMS) National Institutes of Health (NIH)
Treatments:
Caffeine Caffeine citrate Caffeine, sodium benzoate drug combination Sodium Benzoate