A Study to Determine if Caffeine Accelerates Emergence From Propofol Anesthesia
Status:
Completed
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies
clear the anesthetic. Most people wake quickly, but some do not. All patients have memory and
other cognitive problems after waking from anesthesia. In studies on animals, the
investigators observed that caffeine caused rats to wake much more rapidly from propofol
anesthesia. This was true for all the animals tested. The investigators would like to see if
this holds true in humans. Will caffeine accelerate waking from anesthesia? Will it reverse
the cognitive deficits associated with anesthesia, after waking?
The propose investigators carrying out a modest trial with 8 test subjects. Each volunteer
will be anesthetized twice. Each volunteer will be anesthetized one time and receive an
infusion of saline (placebo control), without the aid of any other drugs and the other time
the volunteer will receive an infusion of a relatively low dose of caffeine. The order of
saline versus caffeine will be randomized and the study will be done in a double blind
manner. We will determine whether emergence from propofol anesthesia will be significantly
accelerated by the caffeine infusion. And whether any adverse events are observed.
Phase:
Phase 4
Details
Lead Sponsor:
University of Chicago
Collaborators:
National Institute of General Medical Sciences (NIGMS) National Institutes of Health (NIH)