Overview
A Study to Evaluate the Effect of Co-administration on the Pharmacokinetics of SPR720, Azithromycin, and Ethambutol in Healthy Participants
Status:
Completed
Completed
Trial end date:
2024-02-04
2024-02-04
Target enrollment:
0
0
Participant gender:
All
All
Summary
The primary purpose of this study is to evaluate the pharmacokinetics (PK) of SPR720, azithromycin, and ethambutol, administered separately and co-administered, in healthy adult participants.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Spero TherapeuticsTreatments:
Azithromycin
Ethambutol
Criteria
Inclusion Criteria:- Body mass index (BMI) between ≥18.0 and ≤32.0 kilograms per meter square (kg/m^2) and
weight between 50.0 and 100.0 kilograms (kg) (inclusive) at the Screening visit.
- Medically healthy without clinically significant medical history, abnormalities in
physical examination, laboratory tests, vital signs, or electrocardiogram (ECG) at the
Screening visit.
- Has suitable venous access for repeated blood sampling.
- Has ability and willingness to abstain from alcohol, caffeine, xanthine-containing
beverages or food (coffee, tea, chocolate, and caffeine-containing sodas, colas, etc.)
or products containing any of these from 48 hours prior to study drug administration
until discharge from the clinical research unit (CRU).
Exclusion Criteria:
- Has a history of clinically significant acute illness or surgery within the previous 3
months prior to Screening Visit or Day -1.
- Has a known history of clinically significant hypersensitivity reaction or anaphylaxis
to any medication.
- Has any condition possibly affecting drug absorption (e.g., previous surgery on the
gastrointestinal tract [including removal of parts of the stomach, bowel, liver, gall
bladder, or pancreas]). History of uncomplicated appendectomy ≥1 year prior to
Screening Visit would not be considered exclusionary at the discretion of the
Investigator.
- Is unable to swallow the dosage forms.
- Has received any other investigational medicinal product or participation in another
investigational clinical study that included drug treatment within 30 days prior to
Day 1 dose (based on the timing of the last Follow-up Visit for the previous study to
Day 1 of the current study).
[Note: Other inclusion and exclusion criteria as per protocol may apply.]