Overview

A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM

Status:
Not yet recruiting
Trial end date:
2024-05-01
Target enrollment:
0
Participant gender:
All
Summary
Mavacamtenis a novel, small molecule, selective allosteric inhibitor of cardiac-specific myosin, for the treatment of patients with symptomatic oHCM. This study will assess the efficacy and safety of mavacamten in Chinese adults with symptomatic oHCM.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
LianBio LLC
Criteria
Inclusion Criteria:

- Is at least 18 years old at screening.

- Body weight is greater than 45 kg at screening.

- Has adequate acoustic windows to enable accurate TTEs

- Diagnosed with oHCM

- Has documented LVEF ≥ 55% at rest.

- Has a valid measurement of Valsalva LVOT peak gradient at screening

- Female participants must not be pregnant or lactating

- Able to understand and comply with the study procedures, understand the risks involved
in the study, and provide written informed consent according to national, local, and
institutional guidelines before the first study specific procedure.

Exclusion Criteria:

- Participated in a clinical trial in which the participant received any investigational
drug (or is currently using an investigational device) within 30 days prior to
screening, or at least 5 times the respective elimination half-life (if known),
whichever is longer.

- Causing cardiac hypertrophy in other reasons

- Previously participated in a clinical study with mavacamten.

- Hypersensitivity to any of the components of the mavacamten formulation.

- Current treatment (within 14 days prior to screening) or planned treatment during the
double-blinded treatment with a combination of beta-blockers and verapamil or a
combination of beta-blockers and diltiazem.

- Has been successfully treated with invasive septal reduction

- Has documented obstructive coronary artery disease

- Has known moderate or severe (as per investigator's judgment) aortic valve stenosis,
constrictive pericarditis, or clinically significant congenital heart disease at
screening.

- Has any acute or serious comorbid condition that, in the judgment of the investigator,
could lead to premature termination of study participation or interfere with the
measurement or interpretation of the efficacy and safety assessments in the study.

- History of malignant disease within 10 years of screening

- Has safety laboratory parameters outside normal limits at screening as assessed by the
local laboratory

- Has a positive serologic test at screening for infection with human immunodeficiency
virus, hepatitis C virus, or hepatitis B virus, with the exception of hepatitis B
s-antibody positive, which is a marker of immunity.

- Known infection with COVID-19 (coronavirus disease 2019) within 90 days of screening.

- Has a history or evidence of any other clinically significant disorder, condition, or
disease that, in the opinion of the investigator, would pose a risk to participant
safety or interfere with the study evaluation, procedures, or completion.

- Prior treatment with cardio toxic agents

- Unable to comply with the study requirements, including the number of required visits
to the clinical site

- Is a first degree relative of personnel directly affiliated with the study at the
clinical study site, any study vendor, or the study sponsor.

- Identified as alcohol addicts.