A Study to Evaluate the Efficacy and Safety of Pirfenidone With Novel Coronavirus Infection
Status:
Recruiting
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
The acute lung injury caused by SARS and 2003 were both related to the inflammatory cytokine
storm in patients. The biochemical test showed abnormal increase in related indicators such
as interleukin-8, and CT images showed a medical "white" lung". According to the experience
of SARS treatment in 2003, the use of hormones will indeed help the patients to alleviate
their illness, but patients who survived SARS either had too much hormone at that time and
took too long. Although the lungs could recover, but the femoral head was necrotic Either the
amount of hormones was very conservative at the time, which kept the lungs in the storm of
inflammatory factors, leading to the emergence of irreversible pulmonary fibrosis. So is
there a medicine that can anti-inflammatory, reduce the load of hormone use, and have the
effect of treating and preventing pulmonary fibrosis complicated by severe viral lung? At
present, pirfenidone has achieved encouraging results in the treatment of idiopathic
Pulmonary Fibrosis (CTD-ILD) diseases. It is particularly encouraging that the values
announced at the 2019 ATS Annual Conference suggest that pirfenidone has more
anti-inflammatory and anti-oxidant effects than its own outstanding anti-fibrotic ability.
The data shows early use, Its strong anti-SOD activity can effectively inhibit IL-1beta and
IL-4, and can open the prevention mode of pulmonary interstitial fibrosis. Based on the
above, this project intends to make the following scientific assumptions: based on the
homology of the pathogens of the new coronavirus-infected pneumonia and the coronavirus
infection of pneumonia in 2003, the similarities in the occurrence and development of the
disease, that is, the pulmonary inflammatory storm occurs first, and thereafter The progress
of fibrosis and the progressive decline of lung function and mortality are higher than those
of ordinary pneumonia. We hope that by adding pirfenidone as a treatment program in addition
to standard treatment, it will be a new and severe type of coronavirus infection. Patient
clinical treatment provides an effective and practical method.