A Study to Evaluate the Efficacy of Xlear vs. Placebo for Acute COVID-19 Infection

• Status: Withdrawn
• Trial end date: 2021-08-30
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to find out the efficacy of Xlear nasal spray as an adjunct medication against COVID-19. This encompasses reduction in the number of days to negativization via nasal swab PCR from the average 14 days and early improvement of symptoms.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Larkin Community Hospital

Criteria

Inclusion Criteria:

1. Adults of ages 18 to 90 years of both sexes

2. With positive SARS-CoV-2 carriage confirmed by nasopharyngeal PCR

3. Signed informed consent

4. Mild symptoms: Minimum respiratory symptoms or asymptomatic plus positive test

5. Moderate symptoms: Respiratory symptoms such as cough, mild shortness of breath with mild oxygen desaturation(room air SpO2 <92% and >88% or <88% corrected to >92% with 2 liters of oxygen)

Exclusion Criteria:

1. Patient with very low viral load (threshold cycle [Ct] > 25 per PCR).

2. Known hypersensitivity to one of the constituents, particularly to xylitol or grapefruit seed extract (GSE)

3. Under 18 years of age

4. Women of childbearing age who are pregnant, breastfeeding mothers, and intend to become pregnant during the study period; unwilling/unable to take a pregnancy test.

5. Unable to provide informed consent or decline to consent or unwillingness to adhere to the Standard of Care protocol.

6. Patients with severe symptoms -Hypoxia (SpO2 <88% not corrected by 2 liter non-concentrated oxygen) plus severe shortness of breath

7. History of immunodeficiency or are currently receiving immunosuppressive therapy

8. Have had a planned surgical procedure within the past 12 weeks.

9. Already part of this trial, recruited at a different hospital.

10. Patient unable to perform oro-nasopharyngeal decolonization

11. Patients with acute exacerbation of severe comorbidities like heart disorders Chronic Obstructive Pulmonary Disease (COPD), Heart Failure New York Heart Association (NYHA) Class 3 and 4 and/or diseases with severe oxygenation problems

12. Patients on Remdesivir and/or other clinical trials.