A Study to Evaluate the Relative Bioavailability and Intra-Subject Variability of Two Lots of E5501 40 mg Tablets Administered Twice as Single Oral Doses to Healthy Subjects

• Status: Completed
• Trial end date: 2011-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the relative bioavailability (BA) of two lots of E5501 40 mg tablets administered twice as single oral doses to healthy subjects.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Eisai Inc.

Criteria

Inclusion Criteria:

• Normal healthy adult male or female subjects age greater than or equal to 18 years and less than or equal to 55 years old.

• Body mass index greater than or equal to 18 kg/m2 and less than or equal to 32 kg/m2 at the time of screening.

• Platelet count between 120x109/L and 250x109/L.

• Women of childbearing potential must agree to use a double barrier method of contraception during the Randomization Phase of the study.

Exclusion Criteria:

• Evidence of clinically significant cardiovascular, hepatic, gastrointestinal, renal, respiratory, endocrine, hematologic, neurologic, or psychiatric disease or abnormalities or a known history of any gastrointestinal surgery that could impact the pharmacokinetics (PK)of the study drug.

• Agents associated with thrombotic events (including oral contraceptives) must be discontinued within 30 days of the first study drug administration.

• Evidence of organ dysfunction or any clinically significant deviation from normal in their medical history, e.g., history of splenectomy.

• History of venous or arterial thrombotic disease or other hypercoaguable state.

• Hemoglobin level less than 11.5 g/dL for females and 13.5g /dL for males