A Study to Investigate the Anti-Plaque Effect of AN0128 Toothpaste

• Status: Completed
• Trial end date: 2008-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study was to evaluate the anti-plaque efficacy of the Anacor prototype dentrifice as compared to commercial control products following a single use of the dentrifice.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Pfizer
• Treatments: Anti-Bacterial Agents

Criteria

Inclusion Criteria:

• Must be between ages 18 to 65 years inclusive

• Have a minimum of 16 natural uncrowned teeth (excluding 3rd molars) present

• Must give written informed consent

• Be in good general health

• Must discontinue oral hygiene for 24-hours after initial appointment

• No known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study

Exclusion Criteria:

• Medical condition which requires pre-medication prior to dental visits/procedures

• Advanced periodontal disease

• 5 or more decayed, untreated dental sites

• Diseases of the soft or hard oral tissues

• Orthodontic appliances

• Abnormal salivary function

• Use of drugs that can affect salivary flow

• Use of antibiotics one (1) month prior to or during this study

• Use of any over the counter medications other than analgesics (i.e. aspirin, ibuprofen, acetaminophen, naproxen), unless approved by the study medical staff

• Pregnant or breastfeeding

• Participation in another clinical study in the month preceding this study

• Allergic to common dentifrice ingredients

• Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy)

• History of allergic reaction to any anti-inflammatory agents