A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers

• Status: Completed
• Trial end date: 2017-07-24

Summary

An open-label, non-randomized, 2-arm, 2-period fixed sequence phase 1 study to evaluate the potential inhibition of nitisinone on cytochrome P450 2C9, 2D6, and 2E1 and the organic anion transporters OAT1 and OAT3 in healthy volunteers

• Phase: Phase 1

Details

• Lead Sponsor: Swedish Orphan Biovitrum
• Collaborator: Parexel
• Treatments: Chlorzoxazone; Furosemide; Metoprolol; Nitisinone; Tolbutamide