A Titration Study of a Glucagon-Like Peptide-1 (GLP-1) Analogue in Patients With Type 2 Diabetes Treated With Metformin.
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
This 4 arm study will evaluate the tolerability, efficacy and pharmacodynamics of different
doses of a GLP-1 analogue in patients with type 2 diabetes who are treated with a stable dose
of metformin. Patients will be randomized to receive either subcutaneous placebo, or
subcutaneous GLP-1 analogue (at a dose of 20mg, or a starting dose of 20mg escalating to
either 30mg or 40mg), weekly. All patients will continue on their existing metformin
treatment regimen throughout the study. The anticipated time on study treatment is <3 months,
and the target sample size is 100-500 individuals.