A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery
Status:
Completed
Trial end date:
2020-01-27
Target enrollment:
Participant gender:
Summary
Scoliosis is a disease that involves lateral and/or rotational deformity of the spine and can
affect up to 4% of the population. Typically, surgery is considered when Cobb's angle, which
is a measurement used for evaluation of curves in scoliosis on an anterior-posterior
radiographic projection of the spine, is greater than 50 degrees in the thoracic region (40
degrees in the lumbar region) or when the curvature causes significant pain, or respiratory
and cardiovascular restriction. Patient undergoing this surgical correction experience severe
pain in the postoperative period and the management includes the use of opioid-based
patient-controlled analgesia (PCA).