A Trial of Four Drug Regimens for the Prevention of Malaria in Senegalese Children
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
A recent study has shown that the administration of a single dose of
sulfadoxine/pyrimethamine plus artesunate to Senegalese children on three occasions during a
short malaria transmission season reduced the incidence of clinical attacks of malaria by
86%. However, use of this drug regimen led to the selection of parasites with molecular
markers of resistance to pyrimethamine and sulfadoxine. Therefore, a trial of three
alternative regimens has been undertaken to see if these are as effective and safe as the
drug combination used in the initial study but less likely to select for drug resistance.
Phase:
Phase 3
Details
Lead Sponsor:
Gates Malaria Partnership London School of Hygiene and Tropical Medicine
Collaborators:
Cheikh Anta Diop University, Senegal Institut de Recherche pour le Developpement, Senegal Ministry of Health, Senegal
Treatments:
Amodiaquine Artesunate Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine