A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis

• Status: Completed
• Trial end date: 1998-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, double blind, placebo controlled trial of the use of pentoxifylline (oxpentifylline) for the treatment of recurrent mouth ulcers.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Central Manchester University Hospitals NHS Foundation Trust; Manchester University NHS Foundation Trust
• Treatments: Pentoxifylline

Criteria

Inclusion Criteria:

• Diagnosis of minor recurrent aphthous stomatitis

• 2 or more mouth ulcers per month for more than 6

• No current treatment for oral ulceration or willing to stop treatment

• Age 16 to 65 years

Exclusion Criteria:

• Taking ketorolac, theophylline or anti-hypertensive medication except diuretics (contra-indicated in patients treated with pentoxifylline)

• Systemic diseases that contra-indicate the use of pentoxifylline i.e. pregnancy, hypotension, ischaemic heart disease, acute myocardial infarction, cerebral or occular hemorrhage, renal or hepatic failure, porphyria or allergy to pentoxifylline.

• Patients with an underlying deficiency state or systemic disease that could cause recurrent mouth ulcers e.g. iron, vitamin B12 or foliate deficience, coeliac disease, Crohn's disease, ulcerative colitis, Behcet's disease or Aids.