A Trial of Pyridoxamine to Lower Urine Oxalate in Subjects With Stone Disease or Hyperoxaluria

• Status: Withdrawn
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To determine whether pyridoxamine can decrease oxalate excretion in subjects who have normal oxalate excretion (but who have had kidney stones), and in subjects who have primary hyperoxaluria.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Kansas Medical Center
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Pyridoxamine

Criteria

Inclusion Criteria:

• Adults > 18 years

• History of stone formation

• Good Renal function

• Normal urinary excretion of stone-promoting chemicals(Ca, uric acid, oxalate, citrate), except for subjects with hyperoxaluria for Study

Exclusion Criteria:

• Pregnancy

• Hyperparathyroidism

• Enteric hyperoxaluria.

• Obstructive uropathy

• Infection (struvite) stones

• Severe dietary Ca++ restriction or deficiency

• Recent significant cardio-vascular events