Overview

A Trial to Compare the Pharmacodynamic and Pharmacokinetic Properties of Biochaperone® Combo With Humalog® Mix25 and With Simultaneous Injections of Humalog® and Lantus® in Subjects With Type 2 Diabetes

Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
0
Participant gender:
All
Summary
This is a single centre, randomised, double-blind, double-dummy, 3-treatment, 3-period cross-over, euglycaemic clamp study in subjects with type 2 diabetes on stable insulin treatment. Each subject will be randomly allocated to a treatment sequence and will be administered single subcutaneous doses of 0.8 U/kg Biochaperone® Combo, 0.8 U/kg Humalog® Mix25 or simultaneous subcutaneous injections of 0.2 U/kg Humalog® and 0.6 U/kg Lantus® during three separate dosing visits.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Adocia
Treatments:
Biphasic Insulins
Insulin Glargine
Insulin Lispro
Insulin, Isophane
Criteria
Inclusion Criteria:

- Type 2 diabetes mellitus (as diagnosed clinically) for ≥ 12 months

- HbA1c levels ≤ 9.0%

- Total insulin dose of < 1.2 U/kg/day

- Body mass index between 20.0 and 35.0 kg/m2 (both inclusive)

- Body weight ≤ 125.0 kg

- Fasting serum C-peptide ≤ 1 nmol/L

- Treated with a stable insulin regimen for ≥ 3 months prior to screening

Exclusion Criteria:

- Type 1 diabetes mellitus

- Known or suspected allergy to the trial products or related products

- Previous participation in this trial. Participation is defined as randomised

- Participation in any clinical trial within 3 months prior to this trial

- Clinically significant abnormal haematology, biochemistry, lipids, or urinalysis
screening tests, as judged by the Investigator considering the underlying disease

- Supine blood pressure at screening outside the range of 90-160 mmHg for systolic or
50-95 mmHg for diastolic and/or resting supine heart rate outside the range 50 -90
beats per minute. This exclusion criterion also pertains to subjects being on
antihypertensives

- Use of GLP-1 receptor agonists or oral antidiabetic drugs (OADs) other than stable
intake of metformin within 4 weeks prior to screening

- Women of child bearing potential, not willing to use contraceptive methods