Overview

A Trial to Investigate Different Needle Features Assessed by Comparing Insulin Aspart Pharmacokinetic Profiles

Status:
Completed
Trial end date:
2016-01-28
Target enrollment:
0
Participant gender:
Male
Summary
This trial is conducted in Europe. The aim of the trial is to investigate different needle features assessed by comparing insulin aspart Pharmacokinetics profiles (the exposure of the trial drug in the body)
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Novo Nordisk A/S
Treatments:
Insulin
Insulin Aspart
Insulin degludec, insulin aspart drug combination
Insulin, Globin Zinc
Insulin, Long-Acting
Criteria
Inclusion Criteria:

- Informed consent obtained before any trial-related activities. Trial-related
activities are any procedures that are carried out as part of the trial, including
activities to determine suitability for the trial

- Male, age at least 18 years at time of signing informed consent

- Considered generally healthy upon completion of medical history, physical examination,
analysis of laboratory safety variables, vital signs and ECG (electrocardiogram), as
judged by the investigator

- Body mass index (BMI) 28-39.9 kg/m^2 (overweight to obese)

- Caucasian

Exclusion Criteria:

- Male of reproductive age who or whose partner(s) is not using adequate contraceptive
methods (adequate contraceptive measures as required by local regulation or practice)

- Non-fasting blood glucose test with blood glucose values above 11.1 millimol per liter
(mmol/L)

- HbA1c (Glycosylated Haemoglobin) equal to or above 6.5%

- Known active or in-active skin disease in the injection area or that could affect pain
perception

- History of deep leg vein thrombosis or repeated episodes of deep leg vein thrombosis
in 1st degree relatives (parents, siblings or children) as judged by the investigator

- Use of any prescription or non-prescription medication, including herbal products and
nonroutine vitamins, within the last 2 weeks before screening

- Smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent
per day) who is not able or willing to refrain from smoking or use of nicotine gum or
transdermal nicotine patches during the inpatient period

- Known or suspected abuse of alcohol (defined as regular intake of more than 14 units
weekly for men where 1 unit equals 300 milliliter (mL) of beer, 100 mL of wine, or 25
mL of distilled spirits)

- Positive result of an alcohol breath test

- Known or suspected drug/chemical substance abuse within 1 year from screening