A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
Type 2 diabetes is a major public health problem in India with an estimated a prevalence of
approximately 4% and 12% in rural and urban areas respectively. Accumulating evidence
suggests that serum cholecalciferol levels may be inversely related to the prevalence of
diabetes, insulin resistance and metabolic syndrome. The trials available on the effect of
Vitamin D supplementation on insulin/glucose metabolism have been conducted using small
sample sizes in different subgroups document variable results (significant decrease in HbA1c
concentration with insulin concentration in hemodialysis patients; insulin levels lower with
oral Vitamin D in gestational diabetes; no effect of Vitamin D on serum insulin levels in
post menopausal women). A double blind randomized controlled trial conducted at our institute
using 3,60,000 IU of cholecalciferol over 6 weeks documented improvement in OGIS index of
insulin sensitivity. We therefore, plan to study the long term effect of vitamin D
supplementation on peripheral insulin sensitivity.
Phase:
Phase 4
Details
Lead Sponsor:
Dr Jitender Nagpal
Collaborator:
Indian Council of Medical Research
Treatments:
Cholecalciferol Ergocalciferols Insulin Vitamin D Vitamins