A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children
Status:
Completed
Trial end date:
2018-03-30
Target enrollment:
Participant gender:
Summary
There is a surgical procedure to help children with intractable fecal incontinence gain
continence for stool through construction of a tube that connects the abdominal wall to the
colon near or through the appendix. This tube allows easy administration of enema solution
into the first part of the colon. Putting enema solution through that tube into the colon is
called an antegrade continence enema (ACE) and has been shown to work well in helping some
but not all children prevent stool accidents. The purpose of this study is to compare a large
volume ACE flush using a salt water solution called normal saline with a small volume ACE
flush using liquid glycerin. The aims of this study are to: 1) find the most effective dose
and flush frequency of each solution needed to prevent stool accidents; 2) compare which
solution given at the best dose has the least side effects and 3) to determine if
administration of either of the ACE flushing solutions causes electrolyte abnormalities or
affects colon health.