ABC Blocks for Cardiac Surgery

• Status: Not yet recruiting
• Trial end date: 2024-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This randomized blinded trial aims to evaluate the effect of parasternal intercostal and rectus sheath blocks ("anterior blocks for cardiac surgery" or ABC blocks) on postoperative recovery in patients undergoing median sternotomy for cardiac surgery. Subjects will be randomized to receive either local anesthetic (liposomal bupivacaine plus bupivacaine 0.25%) or saline sham block.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Subjects scheduled for elective cardiac surgery involving primary median sternotomy

• Age 18-85 years of age

• BMI 18-50 kg/m2

Exclusion Criteria:

• Left ventricular ejection fraction (LVEF) < 30%

• Preoperative, intraoperative, or immediate post-operative placement of intra-aortic balloon pump or deployment of extra-corporeal membrane oxygenation (ECMO)

• Inability to understand or speak English

• Allergy to amide local anesthetic

• Contraindication to peripheral nerve block (e.g. local infection, previous trauma to the block site)

• Chronic opioid consumption (daily oral morphine equivalent of >20 mg) in the past three months

• Severe pulmonary disease

• Neurological deficit or disorder

• Suspected or known addition to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past two years

• Uncontrolled anxiety, schizophrenia, or other severe psychiatric disorder