AED/Statin Interaction Study

• Status: Completed
• Trial end date: 2008-09-12
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the amount of the cholesterol-lowering drug atorvastatin available in the bloodstream, when taken together with the anti-seizure drugs lamotrigine or phenytoin.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Anticonvulsants; Atorvastatin; Atorvastatin Calcium; Lamotrigine; Phenytoin

Criteria

Key Inclusion Criteria:

• Body weight >50kg (men) or >45kg (women) and BMI within the range 19-32 kg/m2 inclusive.

• No clinically significant abnormality on clinical examination

Key Exclusion Criteria:

• History or evidence of drug or alcohol abuse or active tobacco use.

• Women of childbearing potential

• Use of prescribed or non-prescribed medications during and within 14 days of starting study medication.