ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study

• Status: Completed
• Trial end date: 2002-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The ASTHMA Pilot Study is a randomized, controlled, parallel group clinical trial of 6 weekly doses of azithromycin (cumulative dose 4800 mg) or placebo as adjunctive treatment in addition to usual care for adults with stable persistent asthma, with final follow up at 3 months after completion of study medication.

The hypothesis to be tested is that antibiotic treatment will improve asthma at followup, and that this improvement will be limited to patients with evidence of C. pneumoniae infection.

The secondary hypothesis is that randomized, controlled treatment trials can be carried out successfully in a geographically dispersed practice-based research network.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wisconsin Research Network
• Treatments: Azithromycin

Criteria

Inclusion Criteria:

• adults with stable persistent asthma and evidence for reversible airway obstruction

Exclusion Criteria:

• macrolide allergy, pregnancy or lactation, specified comorbidities or medications