AT1R Blockade and Periodic Breathing During Sleep in Hypoxia
Status:
Completed
Trial end date:
2019-08-01
Target enrollment:
Participant gender:
Summary
Sleep disordered breathing (SDB) is characterized by regular periods of no breathing (apnea)
or low levels of breathing (hypopnea) and leads to repeated periods of low oxygenation,
termed intermittent hypoxia that causes fluctuations in blood oxygen levels. This leads to
increased peripheral chemoreflex sensitivity that is thought to occur through the stimulation
of angiotensin-II, type-I receptors (AT1R) that are expressed primarily on glomus cells
within the peripheral chemoreflex and ultimately results in long lasting hypertension. The
goal of this study is to determine if AT1R receptor blockade can prevent the increase in
chemoreflex sensitivity following one night of hypoxia and improve the severity of SDB.