AZD2171 and Combination Chemotherapy in Treating Women With Locally Advanced Breast Cancer
Status:
Completed
Trial end date:
2007-07-01
Target enrollment:
Participant gender:
Summary
RATIONALE: AZD2171 may stop the growth of tumor cells by blocking some of the enzymes needed
for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as
doxorubicin, cyclophosphamide, and docetaxel, work in different ways to stop the growth of
tumor cells, either by killing the cells or by stopping them from dividing. Giving AZD2171
together with combination chemotherapy before surgery may make the tumor smaller and reduce
the amount of normal tissue that needs to be removed and may kill more tumor cells.
PURPOSE: This randomized clinical trial is studying how well giving AZD2171 together with
combination chemotherapy works in treating women with locally advanced breast cancer.