Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarker
Status:
Recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
Observation has pointed out, that osteitis present in the MRI scans, predicts bone erosion
and that this in accordance with the concept by underlining the importance of bone marrow
involvement in arthritis [Krabben A, 2013]. Abatacept with its favourable safety profile
preferentially interrupts activation of naïve T cells and perhaps makes the strongest case
for exploiting co-stimulatory blockade during the earliest detectable phase of the adaptive
immune response at a time when predisposition to autoimmune disease can be detected.