Abdominal Nerve Blockade in Chronic Heart Failure.

• Status: Completed
• Trial end date: 2019-12-27
• Target enrollment: 0
• Participant gender: All

Summary

Patients with chronic heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will undergo a regional nerve block of the splanchnic nerves.

This study will be a prospective, uncontrolled clinical trial. The study will not be controlled as invasive monitoring of hemodynamics will be performed, allowing clear demonstration of a cause-effect relationship. The goal of the study is to provide proof of concept.

Patients will undergo detailed physiological testing.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Anesthetics; Anesthetics, Local

Criteria

Inclusion Criteria:

• Diagnosis of heart failure (HF)

• Symptomatic with dyspnea

• On a stable HF drug regimen

Exclusion Criteria:

• Ongoing treatment with oral anticoagulation other than aspirin

• Immunosuppressive medications for solid organ transplant

• Acute MI (STEMI or Type I NSTEMI) within 7 days

• Systolic blood pressure < 90 mmHg or >180 mmHg

• Infiltrative cardiomyopathy or constrictive cardiomyopathy

• Chronic kidney disease stage 5

• Pregnancy