Absorption of Corticosteroids in Children With Juvenile Dermatomyositis

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Juvenile dermatomyositis (JDM) is a connective tissue disease that causes skin rash and weak muscles in children. The purpose of this study is to measure the absorption of oral prednisolone and intravenous (IV) methylprednisolone and to determine levels of disease activity indicators in the blood. These levels will be compared to see if there are patterns specific to active and less active JDM.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Collaborator: Ann & Robert H Lurie Children's Hospital of Chicago
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Juvenile dermatomyositis with evidence of active vasculitis

• Elevated von Willebrand factor antigen prior to study entry

• Elevated neopterin level prior to study entry

Exclusion Criteria:

• Severe renal involvement

• Critically ill or clinically unstable

• Diseases other than dermatomyositis with vasculitis