Abuse Potential of Buprenorphine/Naloxone

• Status: Terminated
• Trial end date: 2006-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Buprenorphine is a treatment for opioid dependence. Naloxone is given in addition to buprenorphine in order to limit the abuse potential that is commonly associated with buprenorphine. The purpose of this study is to determine the abuse potential of high doses of buprenorphine/naloxone in opioid dependent individuals.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Collaborator: Johns Hopkins University
• Treatments: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Naloxone

Criteria

Inclusion Criteria:

• Actively abusing illegal opioids

• Qualifies for opioid substitution treatment (e.g., methadone or buprenorphine), but not in active treatment at the time of study entry

• Meets DSM-IV criteria for opioid dependence

Exclusion Criteria:

• Significant medical problems (e.g., insulin dependent diabetes mellitus)

• Non-substance use psychiatric disorders (e.g., schizophrenia)

• Seeking substance abuse treatment