Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a multicentric randomized phase III trial comparing conventional radiotherapy with concomitant chemotherapy versus accelerated radiotherapy with concomitant chemotherapy versus very accelerated radiotherapy in patients with stage III-IV head and neck squamous cell carcinoma. The main end point is the event free survival.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Groupe Oncologie Radiotherapie Tete et Cou
• Treatments: Carboplatin

Criteria

Inclusion Criteria:

• Squamous cell carcinoma of oral cavity, oropharynx, hypopharynx or larynx

• Stage III-IV (UICC 1997): T2, T3 or T4 with N0-N3 or T0 with N2-N3

• Not resectable

• Karnofsky PS >= 70

• Renal/liver/cardiac functions and blood counts compatible with the use of paraplatin and 5-FU

• Informed consent signed

Exclusion Criteria:

• Distant metastasis

• Contra-indication to concomitant chemotherapy

• History of cancer

• History of head and neck radiotherapy