Acute kidney injury is commonly accompanied major complication after aortic surgery.
Cardipulmonary bypass lyses erythrocyte and induces lipid peroxidation. This increases plasma
free hemoglobin, F2-isoprostane, and isofuran concentration. Cell free hemoglobin have been
reported to be associated with poor prognosis such as acute kidney injury, myocardial
infarction, and death.
Acetaminophen is reported to attenuate hemeprotein mediated lipid peroxidation. Thus,
investigators hypothesized that acetaminophen might have protective effect on the incidence
of acute kidney injury in patients undergoing aortic surgery with moderate hypothermic
circulatory arrest.