Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Acetaminophen is one of the most widely used analgesic in the world, recommended for the
symptomatic treatment of fever and pain.
The purpose of this study is to assess the effectiveness of acetaminophen in association with
N-acetylcysteine.
The objective of this study is to evaluate if the association in healthy volunteers of
acetaminophen and N-acétylcystéine
1. - decrease the antinociceptive effect of acetaminophen in comparison to a group control
2. - and if this antinociceptive effect may depend of the genetic polymorphism of GSH
enzyme.
Phase:
Phase 1
Details
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborators:
Christian DUALE, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital Gilles DUCHEIX, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital Gisèle PICKERING, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital