Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Contrast-Induced Nephropathy

• Status: Completed
• Trial end date: 2004-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Several studies demonstrated a significant reduction of contrast-induced nephropathy (CIN; definition: increase in serum creatinine of >=0.5mg/dl and/or >=25% increase within 48h after contrast-medium) by acetylcysteine (A) or theophylline (T). However, the results are contradictory. Therefore, it was the aim of our double-blind study to compare the effects of A, T, a combination of A and T (A+T), and placebo (P).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität München
• Treatments: Acetylcysteine; N-monoacetylcystine; Theophylline

Criteria

Inclusion Criteria:

• Impaired renal function (serum creatinine >=1.3mg/dl)

• >=100ml of contrast-medium

• Age >= 18years

• Informed consent

Exclusion Criteria:

• Previous dialysis and/or haemofiltration

• Pre-treatment with acetylcysteine and/or theophylline within the last 2 days,

• Pregnancy

• Contraindications to theophylline (untreated high grade arrhythmia or a history of seizures) or acetylcysteine (known allergy).