Acquisition of Responses to a Methamphetamine-associated Cue in Healthy Humans

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to extend our investigations of drug-associated conditioning with healthy volunteers. The investigators have recently completed a pilot study demonstrating that subjects show an increase in self-reported preference for a visual stimulus paired with stimulant drug administration. Furthermore, our pilot data suggest that methamphetamine acts synergistically with rewards in the environment, such that this conditioning effect is facilitated by experiencing the drug in the presence of rewarding, or positive events, such as earning money. The investigators now aim to extend these findings by assessing not only self-reported preference, but also attentional and psychophysiological (electromyogram; EMG) responses to the drug-associated stimuli.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Chicago
• Treatments: Methamphetamine

Criteria

Inclusion Criteria:

• BMI of 19-26kg/m, high school education,

• fluency in English,

• resting blood pressure less than140/90mmHg and consumption of less than 4 standard alcohol or caffeinated drinks per day.

Exclusion Criteria:

• current substance abuse or lifetime substance dependence,

• regular medication,

• history of cardiovascular illness,

• current major Axis I DSM-IV disorder (APA, 2004),

• mood disorder or psychotic symptoms within the past year.

• Shift workers and pregnant or nursing mothers will also be excluded.