Acquisition of Responses to a Methamphetamine-associated Cue in Healthy Humans
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to extend our investigations of drug-associated conditioning with
healthy volunteers. The investigators have recently completed a pilot study demonstrating
that subjects show an increase in self-reported preference for a visual stimulus paired with
stimulant drug administration. Furthermore, our pilot data suggest that methamphetamine acts
synergistically with rewards in the environment, such that this conditioning effect is
facilitated by experiencing the drug in the presence of rewarding, or positive events, such
as earning money. The investigators now aim to extend these findings by assessing not only
self-reported preference, but also attentional and psychophysiological (electromyogram; EMG)
responses to the drug-associated stimuli.