Activation of Brown Adipose Tissue Metabolism Using Mirabegron

• Status: Recruiting
• Trial end date: 2022-05-21
• Target enrollment: 0
• Participant gender: Male

Summary

Could sympathomimetics and sympatholytics drugs safe for the management of Type 2 Diabetes (T2D)? Based on recent evidence, we propose that pharmacological stimulation of Beta-3 adrenergic receptor (ADBR3) at higher doses of Mirabegron may be required to elicit changes in glycemia, but should be combined with Beta-1 adrenergic receptor (ADRB1) antagonists to suppress the unwanted effects on the cardiovascular system.

Together, several results establish a previously unappreciated cross-talk between Gs-coupled ADRB1 and ADRB3 in adipose tissue for the control of glucose homeostasis. Moreover, these data suggest that antagonizing ADRB1 may be a good way to significantly lower the dose of ADRB3 agonist required for glucose control.

Therefore, we believe that there are therapeutic opportunities in targeting adrenergic receptors for the treatment of T2D at least in young/middle aged people.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Université de Sherbrooke
• Collaborator: Laval University
• Treatments: Bisoprolol; Mirabegron

Criteria

Inclusion Criteria:

• Healthy subjects with normal glucose tolerance determined according to an oral glucose tolerance test;

• BMI ≤ 30 kg/m2.

Exclusion Criteria:

• Plasma triglycerides > 5.0 mmol/L at fasting;

• More than 2 alcohol consumption per day;

• More than 1 cigarette per day;

• History of total cholesterol level > 7 mmol/L, of cardiovascular disease, hypertensive crisis;

• Treatment with fibrates, thiazolidinedione, insulin,betablockers or other drugs with effects on insulin resistance or lipid metabolism (exception for antihypertensive drugs, statins or metformin);

• Presence of a noncontrolled thyroid disease, renal or hepatic disease, history of pancreatitis, bleeding diatheses, cardiovascular disease or any other serious medical conditions;

• History of serious gastrointestinal disorders (malabsorption, peptic ulcer, gastroesophageal reflux having required a surgery, etc.); reflux having required a surgery, etc.);

• Presence of a pacemaker;

• Have undergone of PET study or CT scan in the past year;

• Chronic administration of any medication;