Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
In this study the investigators aim to quantitate the extent of cervical and upper thoracic
brown adipose tissue (BAT) activation in lean and obese humans via positron emission
tomography-computed tomography (PET-CT) in response to the non-specific beta adrenergic
receptor (AR) agonist ephedrine. The investigators hypothesise that this pharmacological
adrenergic stimulus will result in activation of BAT in these participants, and that this
activation will be reduced in obese patients. This study will provide important preliminary
information with respect to allowing the investigators to progress with longer trials with
specific beta 3 AR agonists.