Active Bathing to Eliminate Infection (ABATE Infection) Trial

• Status: Completed
• Trial end date: 2019-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The ABATE Infection Project is a cluster randomized trial of hospitals to compare two quality improvement strategies to reduce multi-drug resistant organisms and healthcare-associated infections in non-critical care units. The two strategies to be evaluated are:

• Arm 1: Routine Care Routine policy for showering/bathing

• Arm 2: Decolonization Use of chlorhexidine as routine soap for showering or bed bathing for all patients Mupirocin x 5 days if MRSA+ by history, culture, or screen

Note that enrolled "subjects" represents 53 individual HCA Hospitals (representing ~190 non-critical care units) that have been randomized.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Irvine
• Collaborators: Centers for Disease Control and Prevention; Harvard Medical School; Harvard Medical School (HMS and HSDM); Harvard Pilgrim Health Care; Hospital Corporation of America (HCA); John H. Stroger Hospital; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Rush University

Criteria

Inclusion Criteria:

• All HCA hospitals that reside in the United States

• Note: Unit of randomization is the hospital, but the participants are hospital units

Exclusion Criteria:

• Non-critical care units where chlorhexidine bathing or decolonization for MRSA+ non-critical care patients is routine

• Pediatric, peri-partum, rehabilitation, psychiatry, and BMT units

• Units with >30% cardiac or hip/knee orthopedic surgeries

• Unit average length of stay <2 days

• Patients <12 years-old

• Patients with known allergy to mupirocin or chlorhexidine