Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants
Status:
Not yet recruiting
Trial end date:
2025-02-28
Target enrollment:
Participant gender:
Summary
N,N-dimethyltryptamine (DMT) is a classical psychedelic with similar effects like LSD or
psilocybin. Preliminary evidence from case series and small open-label trials suggests that
psychedelics may be promising candidates for the treatment of several pain-related diseases
such as chronic pain, migraine, cluster headache or phantom limb pain. However, data from
rigorously conducted and randomized clinical trials are lacking. Additionally, the potential
acute analgesic properties of psychedelics remain poorly characterized. Therefore, the
investigators will evaluate the efficacy of DMT on different pain qualities within a model of
electrically induced pain in healthy participants. The analgesic effects will be compared to
racemic ketamine (active control) and placebo within a cross-over design.