Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
Status:
Not yet recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
In a randomized, cross-over study, 20 healthy volunteers will receive a block and replace
therapy that mimics physiological GC rhythm (metyrapone plus hydrocortisone) or placebo.
Participants will undergo two identical overfeeding periods with each treatment. With the
block and replace therapy, food-induced GC peak will be suppressed. Metabolic and autonomic
parameters will be compared to reveal, whether GCs mediate the physiological adaptions to
excessive food intake.
Understanding acute effects of GCs upon food intake is critical, since repetitive disruptions
of GC secretion may become harmful in chronic conditions.