Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects

• Status: Unknown status
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Instituto de Cardiologia do Rio Grande do Sul
• Treatments: Angiotensin I (1-7)

Criteria

Healthy Group Inclusion Criteria:

• arterial pressure <140/90 mmHg

• body mass index (BMI) between 18,5 and 29 Kg/m2

Hypertensive Group Inclusion Criteria:

• anti-hypertensive drug treatment

• ambulatory blood pressure monitoring (ABMP) >130/85 mmHg

• body mass index between 18,5 and 29 Kg/m2

Healthy Group Exclusion Criteria:

• drug treatment

• recent surgeries

• pregnancy

• previous cardiovascular events

• high performance athletes

• dislipidemia

• diabetes

• renal injury

• obesity (BMI above 30 kg/m2)

• alcoholism

• smoking.

Hypertensive Group Exclusion Criteria:

• recent surgeries

• pregnancy

• beta-blockers drug treatment

• previous cardiovascular events

• high performance athletes

• dislipidemia

• diabetes

• renal injury

• obesity (BMI above 30 kg/m2)

• alcoholism

• smoking