Acute Effects of Cannabis on Everyday Life Memory

• Status: Not yet recruiting
• Trial end date: 2026-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine the acute effects of cannabis on various aspects of memory. Eligible participants will complete a drug screen followed by baseline measures of cannabis consumption patterns, level of intoxication, euphoria, anxiety, stress, and verbal intelligence. Next, participants will be randomly assigned to inhale vapor from cannabis containing 20mg THC or placebo; both cannabis and placebo will be obtained from the National Institute on Drug Abuse (NIDA). Participants will complete a battery of memory tests including tests of prospective, verbal, visuospatial, autobiographical, source, verbal working, visuospatial working, false, and temporal order memory. Memory tests will be completed across two blocks in a counterbalanced order. Ratings of intoxication, euphoria, anxiety, and stress will be obtained three additional times after drug/placebo administration. The investigators hypothesize that participants who are randomly assigned to inhale cannabis vapor will perform worse on all memory tests than participants who inhale the placebo.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Washington State University

Criteria

Inclusion Criteria:

• Have used cannabis at least once a week for at least one year

• Willing to abstain from using any cannabis on the day of their scheduled testing session (minimum of 8 hours of abstinence)

Exclusion Criteria:

• Diagnosis of a serious psychiatric condition (psychosis, bipolar I, panic disorder)

• Family history of psychosis

• Diagnosis of a neurological disorder

• Diagnosis of a chronic medical condition (e.g., heart disease, diabetes)

• Diagnosis of a learning disability

• History of multiple concussions

• History of head injury that may impact cognition

• Being pregnant

• Lactating

• History of adverse experiences with cannabis (anxiety, panic attacks)

• Use of illicit drugs in the past 6 months

• Heavy alcohol use (>4 drinks, >4 times/week)

• Smoking/nicotine use