Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)

• Status: Completed
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the effects of cortisol on heroin craving and stress reaction in heroin addicted subjects Randomized, double-blind, placebo-controlled, cross-over, single administration of study medication Study hypothesis:Cortisol has an inhibiting effect on heroin craving and stress reactivity in opioid dependent subjects.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Prof. Dominique de Quervain, MD
• Treatments: Cortisol succinate; Heroin; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Mannitol

Criteria

Inclusion Criteria:

• Age ≥ 18

• Opioid dependency

• Participant in the Janus heroin programme of the UPK Basel

• Able to control parallel consumption of other drugs

• Stable i.v. substitution for at least 3 months

Exclusion Criteria:

• co-morbid psychiatric disturbances

• Current medical conditions excluding participation

• Recent history of systemic or topic glucocorticoid therapy

• known hypersensitivity to the IMP under investigation (cor-tisol)

• pregnancy, breast-feeding

• inability to read and understand the participant's information