Acute Effects of E-Cigarette Aerosol Inhalation

• Status: Recruiting
• Trial end date: 2022-08-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the acute effects of nicotine free electronic cigarette aerosol on vascular function in healthy, non-smokers.

This study comprises a portion of a larger study comparing results of vascular function in nonsmokers to vascular function in healthy smokers chronically exposed to nicotinized electronic cigarette aerosol versus conventional cigarettes.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pennsylvania
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health (NIH)

Criteria

Inclusion Criteria:

• BMI of 18.5 - 30

Exclusion Criteria:

• Cancer

• HIV

• Mental illness

• Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks)

• Serious arrhythmias

• Bronchospastic disease

• Upper respiratory tract infection within the past six weeks

• Chronic medication or antibiotics

• Claustrophobia / contraindications for MRI