Acute Effects of Furosemide on Hemodynamics and Pulmonary Congestion in Acute Decompensated Heart Failure.
Status:
Completed
Trial end date:
2024-02-09
Target enrollment:
Participant gender:
Summary
Intravenous (IV) loop diuretics have been a key component in treating pulmonary edema since
the 1960s and has a Class 1 recommendation in the 2021 guidelines for acute heart failure.
However, no randomized clinical trials have investigated loop diuretics versus other
interventions for acute heart failure, and clinical knowledge of the hemodynamic effects of
furosemide is based in studies from the 1970s. In this study, we aim to assess the acute
effect of furosemide on cardiac filling pressures and pulmonary congestion.
Hypothesis:
Administration of furosemide induces a hyperacute (within 30 minutes) lowering of cardiac
filling pressures and pulmonary congestion before significant diuresis occurs.
Design:
A prospective, interventional study including 20 patients admitted due to a clinical
diagnosis of acute heart failure with pulmonary congestion.
Intervention:
80 mg of furosemide is administered IV. Measurements include blood pressure, peripheral
oxygen saturation, pulmonary fluid content by ReDS*, ultrasound examination of heart and
lungs, and assessment of cardiac filling pressures with doppler and strain analysis.
Measurements are repeated at several time points until 6 hours have passed.