Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EES

• Status: Enrolling by invitation
• Trial end date: 2023-05-04
• Target enrollment: 0
• Participant gender: All

Summary

In a current first-in-man study, called Stimulation Movement Overground (STIMO) (NCT02936453; CER-VD: 04-2014; Swissmedic: 2016-MD-0002), epidural electrical stimulation (EES) of the spinal cord is applied to enable individuals with severe spinal cord injury (SCI) to complete intensive locomotor neurorehabilitation training. In this clinical feasibility study, it was demonstrated that EES results in an immediate enhancement of locomotor functions and that when applied repeatedly as part of a neurorehabilitation program, EES can progressively improve leg motor control in individuals with severe SCI. Mechanistically, EES acts trans-synaptically upon spinal circuitries through the electrical stimulation of proprioceptive fibers.

It is assumed that this stimulation does not increase the level of availability of monoamine neurotransmitters below the SCI level, which are essential for lower extremity movement generation. Specifically, in a non-injured individual, dopamine and serotonin synthesized in the brain and brainstem are released by fibers diffusely innervating the spinal cord, serving to critically mediate excitability of motor neurons and interneurons in lumbar and sacral spinal level. Spinal cord injury would partially or entirely disrupt these modulation pathways, resulting in a detrimental lack of crucial neurotransmitters below the injury level. This lack of endogenous neurotransmitters could potentially be compensated for by pharmacological agents promoting the neurochemical environment necessary for locomotion.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre Hospitalier Universitaire Vaudois
• Collaborator: Ecole Polytechnique Fédérale de Lausanne
• Treatments: Buspirone; Carbidopa; Carbidopa, levodopa drug combination; Levodopa

Criteria

Inclusion Criteria:

• Completed the main phase of the STIMO study

• Enrolled in the STIMO study extension

• Age 18-65 (women or men)

• Sensorimotor or motor complete and incomplete SCI graded as AIS A, B, C & D

• Stable medical, physical and psychological condition as considered by Investigators

• Able to understand and interact with the study team in French or English

• Adequate caregiver support and access to appropriate medical care in the patient's home community

• Agree to comply with all conditions of the study and to attend all required study training and visit

• Must provide and sign Informed Consent prior to any study-related procedures

Exclusion Criteria:

• Epilepsy

• Women who are pregnant (pregnancy test obligatory for women of childbearing potential) or breastfeeding or not willing to take contraception.

• Known or suspected non-compliance, drug or alcohol abuse.

• Gastrointestinal ulcers in the last five years

• Known or suspected eye disorders or diseases

• Known or suspected allergies or hypersensitivity to buspirone, levodopa or carbidopa.

• Taking selective and non-selective serotonin reuptake inhibitors or any other treatments acting upon serotonergic transmission, such as the following:

• Selective serotonin reuptake inhibitors (SSRIs)

• Serotonin-norepinephrine reuptake inhibitors (SNRIs)

• Serotonin antagonists and reuptake inhibitors (SARIs)

• Tricyclic antidepressants (TCAs)

• Tetracyclic antidepressants (TeCAs)

• Norepinephrine-dopamine reuptake inhibitors (NDRIs)

• Monoamine oxidase inhibitors (MAOIs)

• Patients who are receiving treatments altering the noradrenergic and dopaminergic transmission (e.g., bupropion and levodopa/carbidopa)

• Patients who are taking narcotic pain killers (e.g., opioids) and neuropathic medication (e.g., gabapentin, pregabalin)

• Patients who are taking antihypertensive drugs and diuretics (e.g., furosemide or hydrochlorothiazide)

• Patients who are taking hypnotic drugs (e.g., Zolpidem).

• Patients receiving D2 antagonists or antipsychotic drugs (e.g., butyrophenone, phenothiazines, risperidone)

• Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)