Acute Hemodynamic Effect of Acetazolamide in Pulmonary Hypertension

• Status: Completed
• Trial end date: 2019-04-05
• Target enrollment: 0
• Participant gender: All

Summary

To study the acute effect of acetazolamide (AZA) on pulmonary hemodynamics in patients with pulmonary hypertension (PH) undergoing clinically indicated right heart catheterisation (RHC).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zurich
• Treatments: Acetazolamide

Criteria

Inclusion Criteria:

• All patients undergoing RHC for a clinical indication and who are diagnosed with precapillary PH (mPAP ≥25 mmHg, pulmonary wedge pressure (PAWP) ≤15mmHg)

Exclusion Criteria:

• Patients in whom a RHC is clinically not indicated

• pregnant women

• PH in left heart disease or with more than mild chronic obstructive pulmonary disease or restrictive lung disease.