Acute Metabolic Effects of Melatonin Treatment

• Status: Completed
• Trial end date: 2020-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

Modern living is associated with an epidemic of type 2 diabetes mellitus (T2DM). Sleep disturbances are strong independent risk factors for incident diabetes. Melatonin has been implicated in regulation of circadian rhythm and sleep, but it is also ascribed anti-oxidative properties and effects on glucose homeostasis. A potential association between melatonin and T2DM has only been addressed in few human physiological studies, but the topic has received renewed interest since genetic-epidemiological studies have pointed to a role for melatonin in the development of the disease. In the current study, the investigators wish to examine whether treatment with synthetic melatonin induces physiological changes that affect the risk of developing type 2 diabetes. Two studies of the physiological effects of melatonin are included in the present protocol. In study A, the investigators will examine the acute effects of Melatonin on insulin secretion and insulin sensitivity using a Botnia clamp and in study B the investigators will examine the potential effects of Melatonin on the incretin response.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Collaborator: University of Copenhagen
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Male sex

• Age 20-40 years

• BMI between 22-30 kg/m2

• Written consent prior to study participation

Exclusion Criteria:

• Diabetes or impaired glucose tolerance (fasting p-glucose ≥ 6.1mmol/L)

• Daily use of a prescription drug

• Shift work within the last year

• Travel across >2 time zones in the past three months

• Use of melatonin on a regular basis within the last year

• Severe illness

• High performance athletes

• Daily tobacco smoking

• Previous diagnosis of a sleep disorder

• Present or earlier alcohol or drug abuse

• Unable to give informed consent

• Allergy towards melatonin