Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before initiating cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not been well established.

Patients undergoing cardiac surgery employing moderate hypothermic CPB (n=40) are randomly allocated into one of two groups: in Group-ANH(n=20), ANH is applied by using a balanced hydroxyethyl starch (HES 130/0.6); and in Group-C, ANH is not applied.

After weaning from CPB, intergroup differences of INTEM, EXTEM, FIBTEM and APTEM profiles are analyzed.

As a primary outcome, inter-group difference between maxiaml clot firmness of EXTEM will be determined at 10 min after ANH in Group-ANH and that at control.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Konkuk University Medical Center

Criteria

Inclusion Criteria:

• patients undergoing cardiac surgery with cardiopulmonary bypass who signed written informed consent

Exclusion Criteria:

• preoperative renal failure requiring reran replacement therapy

• preoperative liver disease

• preoperative low cardiac output (EF < 50%)

• Preoperative IABP application, Atrial fibrillation, Pacemaker,

• contraindication for applying TEE

• intraoperative withdrawal