Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft
Status:
Unknown status
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
Reperfusion of renal graft in kidney transplantation can change the
pharmacokinetic-pharmacodynamic (PKPD) parameters of rocuronium. The immediate increase of
urine output during surgery may change the PKPD parameters of the drugs, including
elimination rate. The goal of this study is to characterize the PKPD model of rocuronium
during kidney transplantation and establish a basis for adequate dosage of rocuronium in
kidney transplantation.
Through PKPD modeling, the changes during reperfusion of the renal graft will be evaluated.
Furthermore, the factors related to the changes will be assessed. Adjusting the infusion rate
according to the step of kidney transplantation will lead to stable muscle relaxation and
fast recovery.