Acute Regulation of Intestinal and Hepatic Lipoprotein Production by Glucagon
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
Insulin resistant states are characterized by hepatic lipoprotein (VLDL) particle
overproduction. Numerous hormonal and nutritional factors are known to influence hepatic
lipoprotein particle production, including insulin and free fatty acids (FFA). In contrast to
the liver, the intestine has traditionally been viewed as a 'passive' organ with respect to
lipoprotein production, with intestinal lipoprotein particle production determined mainly by
the amount of fat ingested and absorbed. Glucagon plays a key role in the regulation of
carbohydrate and fatty acid metabolism and has recently been shown for the first time to
regulate hepatic lipoprotein production in mice. Ours will be the first study to investigate
the effect of glucagon on hepatic and intestinal lipoprotein production in humans.